G. Asher Newsome

Research Physical Scientist

 

Phone: 301-238-1223
Fax: 301-238-3709
E-mail Address: NewsomeG [at] si.edu

Address:
Museum Conservation Institute
Smithsonian Institution
4210 Silver Hill Road
Suitland, MD 20746


Education

PhD, Chemistry, University of North Carolina - Chapel Hill, NC (2009)
MS, Chemistry, University of North Carolina - Chapel Hill, NC (2007)
BS, Chemistry, University of Georgia, Athens, GA (2005)

Research Methods and Technical Skills

  • Mass Spectrometry and Analytical Separation Chemistry
  • Orbitrap and Hybrid Analyzer Mass Spectrometry
  • Triple Quadrupole and Quadrupole Ion Trap Mass Spectrometry
  • Liquid Chromatography
  • Time-of-flight Mass Spectrometry
  • Gas Chromatography
  • Data Analysis and Statistical Applications

 

Recent Research Activities

New Methods in Gas Chromatography-Mass Spectrometry

  • Improvement to Chemical Ionization (CI) Methods
  • Preconcentration of Ammonium Nitrate Degradation Products
  • Coupling to High Resolution Mass Spectrometry

Ambient Mass Spectrometry

  • Analysis for Explosives and Involatile and Volatile Compounds in Ambient Headspace
  • Measurement of Ambient Humidity Effects on Post-plasma Ionization
  • Routine Analysis of Surfaces and Coupling to Gas Chromatography

Food Allergen Quantification by Liquid Chromatography-Mass Spectrometry

  • Selected Reaction Monitoring of Bovine Alpha-S1-casein Peptides
  • Analyte and Internal Standard Recovery in Food Matrices
  • Setup of Portable Ion Trap Mass Spectrometer
  • Participation in Round-Robin Assay Testing

Professional Activities

2010-present Washington-Baltimore Mass Spectrometry Discussion Group
co-chair 2013-2015; webmaster 2016-present

2010-present American Chemical Society

2007-present American Society for Mass Spectrometry

 

Recent Publications

Newsome, G. A.; Steinkamp, F. L.; Giordano, B. C. Isobutane Made Practical as a Reagent Gas for
Chemical Ionization Mass Spectrometry, 2016, J. Am. Soc. Mass Spectrom., 27 (11), p 1789–1795.

Newsome, G. A.; Ackerman, L. K.; Johnson, K. J. Humidity Effects on Fragmentation in Plasmabased
Ambient Ionization Sources, 2016, J. Am. Soc. Mass Spectrom., 27 (1), 135-143.

Baucom, J. N. Merrill, M. H.; Field, C. R.; Newsome, G. A.; Johnson, K. J. Effect of Placing a Probe in an Acoustic Drop Levitator, 2016, J. Vib. Acoust., 138, 011011.

Lubrano, A. L.; Field, C. R.; Newsome, G. A.; Rogers, D. A.; Giordano, B. C.; Johnson, K. J.
Minimizing Thermal Degradation in Gas Chromatographic Quantitation of Pentaerythritol Tetranitrate, 2015, J. Chrom. A., 1394, 154-158.

Newsome, G. A.; Ackerman, L. K.; Johnson, K. J. Humidity Affects Relative Ion Abundance in Direct Analysis in Real Time Mass Spectrometry of Hexamethylene Triperoxide Diamine, 2014,
Anal. Chem., 86, 11977-11980.

Grundy, H. H.; et al. Selected Reaction Monitoring Method to Determine the Species Origin of Blood-based Binding agents in Meats: A Collaborative Study, 2013, Food Chem., 141, 3531-3536.

Newsome, G. A.; Scholl, P. F. Selected Reaction Monitoring Quantification of the Allergenic Bovine Milk Protein alpha-S1-casein in Baked Goods Using an Intact Labeled Protein Internal Standard,
2013, J. Ag. Food Chem., 61, 5659-5668.

Newsome, G. A.; Glish, G. L. A New Approach to IRMPD for Controlled Dissociation in a Quadrupole Ion Trap, 2011, J. Am. Soc. Mass Spectrom., 22 (2), 207-213.

Newsome, G. A.; Glish, G. L. Improving IRMPD in a Quadrupole Ion Trap, 2009, J. Am. Soc. Mass
Spectrom., 20, 1127-1131.

Bowers, J. E.; et al. Comparative Physical Mapping Links Conservation of Microsynteny to Chromosome Structure and Recombination in Grasses, 2005, Proc. Nat. Acad. Sci. U.S.A., 102 (37), 13206-13211.

Newsome, G. A.; Rosen, E. P.; Kamens, R. M.; Glish, G. L. Real-Time Detection of Secondary Organic Aerosols with a Quadrupole Ion Trap, Anal. Chem., submitted.

Memo Reports to the U.S. Navy

Newsome, G. A.; Steinkamp, F.L.; Giordano, B.C.; Headspace Analysis of Ammonium Nitrate,
2015.

DeGreeff, L.E.; Newsome, G. A.; Katilie, C.J.; Johnson, K.J.; Rose-Pehrsson, S.L. Headspace
Analysis of Hexamethylene Triperoxide Diamine (HMTD), 2015.

Recent Presentations

2016 Newsome, G. A.; Steinkamp, F.L.; Giordano, B.C.; “Isobutane Made Practical as a Reagent Gas for
Chemical Ionization Mass Spectrometry” Oral Presentation, the 37th East Coast Ion Chemistry
Conference, Newark, DE 64th ASMS Conference on Mass Spectrometry, San Antonio, TX

2016 Newsome, G. A.; Steinkamp, F.L.; Giordano, B.C.; Collins, G.E. “Isobutane as a Reagent Gas for
Chemical Ionization Mass Spectrometry of Explosives and Drugs” Poster Presentation, 8th Annual Workshop on Trace Explosives Detection, Charlottesville, VA

2015 Newsome, G. A.; Steinkamp, F.L.; Giordano, B.C.; "Preconcentration of Ammonium Nitrate Headspace for CI and EI Mass Spectrometry” Poster Presentation, the 63rd ASMS Conference on Mass Spectrometry, St. Louis, MO

2014 Newsome, G. A.; Steinkamp, F.L.; Giordano, B.C.; “Characterization of Ammonium Nitrate Vapor with Flowing Atmospheric-Pressure Afterglow Mass Spectrometry” Poster Presentation, the 20th International Mass Spectrometry Conference, Geneva, Switzerland 62nd ASMS Conference on Mass Spectrometry, Baltimore, MD 6th Annual Workshop on Trace Explosives Detection, Charlottesville, VA

2014 Newsome, G. A.; Johnson. K.J.; “Relative Humidity Control for Reproducible Atmospheric Pressure
Chemical Ionization Mass Spectrometry” Poster Presentation, the 62nd ASMS Conference on
Mass Spectrometry, Baltimore, MD

2013 Newsome, G. A.; DeGreeff, L.E.; Katilie, C.J.; Johnson, K.J.; “Detection of Explosive Molecular
Adduct Ions with Flowing Atmospheric-Pressure Afterglow Mass Spectrometry” Poster
Presentation, the 61st ASMS Conference on Mass Spectrometry, Minneapolis, MN 5th Annual Workshop on Trace Explosives Detection, Philadelphia, PA

2012 Newsome, G. A.; Callahan, J. H.; Jackson, L. S.; Al-Taher, F.; Scholl, P. F.; “SRM Quantitation of
Allergenic Milk in Commercial and Model Baked Goods Using an 15N-labeled Intact Protein Internal Standard” Poster Presentation, the 60th ASMS Conference on Mass Spectrometry, British Columbia, Canada 2nd Annual FDA Foods Program Science and Research Conference, Silver Spring, MD

2012 Scholl, P. F.; Newsome, G. A. “Quantitative Analysis of Food Allergens: A Case Study of the Selected Reaction Monitoring of α-S1-casein in Baked Goods Using an Intact 15N-labeled Protein Internal Standard” Oral Presentation, the 243rd ACS National Meeting, San Diego, CA

2011 Newsome, G. A.; Callahan, J. H.; Scholl, P.F. “Improved Recovery of Milk Peptides from Digests and Calibration Standard Solutions for the Regulatory Analysis of Allergenic Food Proteins” Poster Presentation, the 59th ASMS Conference on Mass Spectrometry, Colorado, CO 1st Annual FDA Foods Program Science and Research Conference, Silver Spring, MD

2011 Scholl, P.F.; Newsome, G. A.; Callahan, J. H. “Development of a Mass Spectrometric Assay for Quantitative Analysis of the Allergenic Milk Protein α-S1-Casein Utilizing an Intact 15N-labeled Protein Internal Standard” Poster Presentation, 1st Annual FDA Foods Program Science and Research Conference, Silver Spring, MD

2011 Wongkongkathep, P.; Newsome, G. A.; Tolocka, M.; Glish, G. L. “Localized Laser Heating for
Vaporization of Particles in an Aerosol Quadrupole Ion Trap Mass Spectrometer” Poster Presentation, the 59th ASMS Conference on Mass Spectrometry, Colorado, CO

2010 Newsome, G. A.; Zhong, A. Z.; Glish, G. L. “Profiling Two-Dimensional Ion Cloud Distribution in a Quadrupole Ion Trap Mass Spectrometer with Infrared Multiphoton Photodissociation” Poster Presentation, the 58th ASMS Conference on Mass Spectrometry, Salt Lake City, UT

2010 Scholl, P.; Newsome, G. A.; Shefcheck, K.; Callahan, J. H.; Ross, M. M. “Development of a Scheduled-MRM Assay for Regulatory Analysis of the Allergenic Milk Protein α-S1-Casein Utilizing an Intact 15N-Labeled Internal Standard” Poster Presentation, the 58th ASMS Conference on Mass Spectrometry, Salt Lake City, UT