All Smithsonian museums in Washington, D.C., including the National Zoo, and in New York City continue to be closed to support the effort to contain the spread of COVID-19.
- Hide: Skin as Material and Metaphor: Part II September 4, 2010 – January 16, 2011 American Indian Museum Heye Center
- Elephant Trails September 3, 2010 – Permanent National Zoo
- Americans Now August 20, 2010 – July 10, 2011 Portrait Gallery
- Brave New World August 9, 2010 – November 27, 2011 African Art Museum
- Grass Roots: African Origins of an American Art June 23, 2010 – November 28, 2010 African Art Museum
- The Healing Power of Art: Works of art by Haitian children after the earthquake June 17, 2010 – February 27, 2011 African Art Museum
- Paper Engineering: Fold, Pull, Pop & Turn June 14, 2010 – September 5, 2011 American History Museum
- Cosmos in Miniature: The Remarkable Star Map of Simeon De Witt May 28, 2010 – December 5, 2010 American History Museum
- The David H. Koch Hall of Human Origins: What Does It Mean To Be Human? March 17, 2010 – Permanent Natural History Museum
- Hide: Skin as Material and Metaphor: Part I March 6, 2010 – August 1, 2010 American Indian Museum Heye Center
- Glimpse of the Past: A Neighborhood Evolves March 5, 2010 – September 25, 2011 Portrait Gallery
- A Letter from George Washington, November 30, 1785 February 25, 2010 – May 7, 2010 American History Museum
- One Life: Echoes of Elvis January 8, 2010 – August 29, 2010 Portrait Gallery
- A Song for the Horse Nation November 14, 2009 – July 7, 2011 American Indian Museum Heye Center
- Keeping History: Plains Indian Ledger Drawings November 13, 2009 – January 31, 2010 American History Museum
- Yinka Shonibare MBE November 10, 2009 – March 7, 2010 African Art Museum
- IndiVisible: African-Native American Lives in the Americas November 10, 2009 – May 31, 2010 American Indian Museum
- Portraiture Now: Communities November 6, 2009 – July 5, 2010 Portrait Gallery
- Outwin Boochever Portrait Competition 2009 October 23, 2009 – September 6, 2010 Portrait Gallery
- Brian Jungen: Strange Comfort October 16, 2009 – August 8, 2010 American Indian Museum
- Faces of the Frontier: Photographic Portraits from the American West, 1845-1925 September 25, 2009 – January 24, 2010 Portrait Gallery
- Bittersweet Harvest: The Bracero Program, 1942-1964 September 9, 2009 – January 3, 2010 American History Museum
- Delivering Hope: FDR & Stamps of the Great Depression September 9, 2009 – June 7, 2010 Postal Museum
- One Life: Thomas Paine, The Radical Founding Father August 7, 2009 – November 29, 2009 Portrait Gallery
